Holy Cross Home Science College, Thoothukudi, established in 1975, is administered by the society of the Sisters of the Cross of Chavanod, Madurai Province. The college is affiliated to Manonmaniam Sundaranar University, Tirunelveli. It was Re-accredited with 'B' grade by NAAC.
In order to create an aesthetic sense among the women of Thoothukudi, the sisters dreamed of starting a technical institution. The campus which housed the Tamil Literature Society was purchased by the sisters in 1955 from the Tuticorin Diocesan Association represented by the Bishop of Tuticorin.